Abstract
COVID-19 is a coronavirus infection of the respiratory system, with multiorgan involvement. Acute kidney injury (AKI) is one of the complications of covid-19 infection. This review explored the epidemiology, pathophysiology, risk factors, and outcome of AKI in Covid-19 infection. There is huge variability in the incidence of AKI among COVID-19 patients from different regions of the world. Some modifiable and non-modifiable risk factors that can increase a patient’s risk of developing AKI have been identified. Mortality is significantly increased if a COVID-19 patient develops AKI. Avoidance of risk factors and improve survival and reduce morbidity among patients. Long term follow up is recommended for survivors with AKI to monitor for future kidney disease.
References
Goudouris ES. Laboratory diagnosis of COVID-19. J Pediatr (Rio J). 2021 Jan-Feb;97(1):7-12. doi: 10.1016/j.jped.2020.08.001. Epub 2020 Aug 31. PMID: 32882235; PMCID: PMC7456621.
Murray, Patrick and Witebsky, F.G.. The Clinician and the Microbiology Laboratory. 2014;1: 233-265. 10.1016/B978-1-4557-4801-3.00016-3.
Pretorius M. and Venter M.. Diagnosis of viral infections. Viral infections in children. 2017 May 5; 1:151-182.
Riou J, Althaus CL. Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 [published correction appears in Euro Surveill. 2020 Feb;25(7):]. Euro Surveill. 2020;25(4):2000058. doi:10.2807/1560-7917.ES.2020.25.4.2000058..
Parry J. China coronavirus: cases surge as official admits human to human transmission. BMJ. 2020;368:m236. Published 2020 Jan 20. doi:10.1136/bmj.m236.
Kim JY, Ko JH, Kim Y, et al. Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea. J Korean Med Sci. 2020;35(7):e86. Published 2020 Feb 24. doi:10.3346/jkms.2020.35.e86.
Lauer SA, Grantz KH, Bi Q, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020;172(9):577-582. doi:10.7326/M20-0504.
Naicker S, Yang CW, Hwang SJ, Liu BC, Chen JH, Jha V. The Novel Coronavirus 2019 epidemic and kidneys. Kidney Int. 2020;97(5):824-828. doi:10.1016/j.kint.2020.03.001.
F Fisher M, Neugarten J, Bellin E, et al. AKI in Hospitalised Patients with and without COVID-19: A Comparison Study. J Am Soc Nephrol. 2020;31(9):2145-2157. doi:10.1681/ASN.2020040509.
Coca SG, Singanamala S, Parikh CR. Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. Kidney Int. 2012;81(5):442-448. doi:10.1038/ki.2011.379.
Khwaja A. Kidney disease: Improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2:1-138.
Fabrizi F, Alfieri CM, Cerutti R, Lunghi G, Messa P. COVID-19 and Acute Kidney Injury: A Systematic Review and Meta-Analysis. Pathogens. 2020;9(12):1052. doi:10.3390/pathogens9121052
Lin L, Wang X, Ren J, et al. Risk factors and prognosis for COVID-19-induced acute kidney injury: a meta-analysis. BMJ Open. 2020;10(11):e042573. Published 2020 Nov 10. doi:10.1136/bmjopen-2020-042573.
Raina R, Mahajan ZA, Vasistha P, Chakraborty R, et. al. Incidence and Outcomes of Acute Kidney Injury in COVID-19: A Systematic Review. Blood Purification. 2021 Jun 15:1-4.
Xu Z, Tang Y, Huang Q, et al. Systematic review and subgroup analysis of the incidence of acute kidney injury (AKI) in patients with COVID-19. BMC Nephrol. 2021;22(1):52. Published 2021 Feb 5. doi:10.1186/s12882-021-02244-x.
Zheng X, Zhao Y, Yang L. Acute Kidney Injury in COVID-19: The Chinese Experience. Semin Nephrol. 2020;40(5):430-442. doi:10.1016/j.semnephrol.2020.09.001.
Sundaram S, Soni M, Annigeri R. Urine abnormalities predict acute kidney injury in COVID-19 patients: An analysis of 110 cases in Chennai, South India. Diabetes Metab Syndr. 2021;15(1):187-191. doi:10.1016/j.dsx.2020.12.021.
Hirsch JS, Ng JH, Ross DW, et al. Acute kidney injury in patients hospitalised with COVID-19. Kidney Int. 2020;98(1):209-218. doi:10.1016/j.kint.2020.05.006.
See YP, Young BE, Ang LW, et al. Risk Factors for Development of Acute Kidney Injury in COVID-19 Patients: A Retrospective Observational Cohort Study. Nephron. 2021;145(3):256-264. doi:10.1159/000514064.
Chan L, Chaudhary K, Saha A, et al. AKI in Hospitalised Patients with COVID-19. J Am Soc Nephrol. 2021;32(1):151-160. doi:10.1681/ASN.2020050615.
Jayaraj VJ, Rampal S, Ng CW, Chong DWQ. The Epidemiology of COVID-19 in Malaysia. Lancet Reg Health West Pac. 2021;17:100295. doi:10.1016/j.lanwpc.2021.100295.
Sim BLH, Chidambaram SK, Wong XC, et al. Clinical characteristics and risk factors for severe COVID-19 infections in Malaysia: A nationwide observational study. Lancet Reg Health West Pac. 2020;4:100055. doi:10.1016/j.lanwpc.2020.100055
Jiang S, Hillyer C, Du L. Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses [published correction appears in Trends Immunol. 2020 Apr 24;:]. Trends Immunol. 2020;41(5):355-359. doi:10.1016/j.it.2020.03.007.
Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280.e8. doi:10.1016/j.cell.2020.02.052.
J Farkash EA, Wilson AM, Jentzen JM. Ultrastructural Evidence for Direct Renal Infection with SARS-CoV-2 [published correction appears in J Am Soc Nephrol. 2020 Oct;31(10):2494]. J Am Soc Nephrol. 2020;31(8):1683-1687. doi:10.1681/ASN.2020040432.
Su H, Yang M, Wan C, et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020;98(1):219-227. doi:10.1016/j.kint.2020.04.003.
Schurink B, Roos E, Radonic T, et al. Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study. Lancet Microbe. 2020;1(7):e290-e299. doi:10.1016/S2666-5247(20)30144-0.
Hanley B, Naresh KN, Roufosse C, et al. Histopathological findings and viral tropism in UK patients with severe fatal COVID-19: a post-mortem study. Lancet Microbe. 2020;1(6):e245-e253. doi:10.1016/S2666-5247(20)30115-4.
Hanley B, Naresh KN, Roufosse C, et al. Histopathological findings and viral tropism in UK patients with severe fatal COVID-19: a post-mortem study. Lancet Microbe. 2020;1(6):e245-e253. doi:10.1016/S2666-5247(20)30115-4.
Diao B, Wang C, Wang R, et al. Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection. Nat Commun. 2021;12(1):2506. Published 2021 May 4. doi:10.1038/s41467-021-22781-1.
Sun J, Zhu A, Li H, et al. Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient. Emerg Microbes Infect. 2020;9(1):991-993. doi:10.1080/22221751.2020.1760144.
Yao H, Song Y, Chen Y, et al. Molecular Architecture of the SARS-CoV-2 Virus. Cell. 2020;183(3):730-738.e13. doi:10.1016/j.cell.2020.09.018.
Glowacka I, Bertram S, Müller MA, et al. Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response. J Virol. 2011;85(9):4122-4134. doi:10.1128/JVI.02232-10.
Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280.e8. doi:10.1016/j.cell.2020.02.052.
Ye M, Wysocki J, William J, Soler MJ, Cokic I, Batlle D. Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes. J Am Soc Nephrol. 2006;17(11):3067-3075. doi:10.1681/ASN.2006050423.
Reddy R, Asante I, Liu S, et al. Circulating angiotensin peptides levels in Acute Respiratory Distress Syndrome correlate with clinical outcomes: A pilot study. PLoS One. 2019;14(3):e0213096. Published 2019 Mar 7. doi:10.1371/journal.pone.0213096.
Reddy R, Asante I, Liu S, et al. Circulating angiotensin peptides levels in Acute Respiratory Distress Syndrome correlate with clinical outcomes: A pilot study. PLoS One. 2019;14(3):e0213096. Published 2019 Mar 7. doi:10.1371/journal.pone.0213096.
Batlle D, Soler MJ, Sparks MA, et al. Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology. J Am Soc Nephrol. 2020;31(7):1380-1383. doi:10.1681/ASN.2020040419.
Dudoignon E, Moreno N, Deniau B, et al. Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19. Anaesth Crit Care Pain Med. 2020;39(4):453-455. doi:10.1016/j.accpm.2020.06.006
Ozkan S, Cakmak F, Konukoglu D, et al. Efficacy of Serum Angiotensin II Levels in Prognosis of Patients With Coronavirus Disease 2019. Crit Care Med. 2021;49(6):e613-e623. doi:10.1097/CCM.0000000000004967.
Legrand M, Bokoch MP. The Yin and Yang of the Renin-Angiotensin-Aldosterone System in Acute Kidney Injury. Am J Respir Crit Care Med. 2021;203(9):1053-1055. doi:10.1164/rccm.202012-4419ED.
Hall A, Busse LW, Ostermann M. Angiotensin in Critical Care. Crit Care. 2018;22(1):69. Published 2018 Mar 20. doi:10.1186/s13054-018-1995-z
de Abajo FJ, Rodríguez-Martín S, Lerma V, et al. Use of renin-angiotensin-aldosterone system inhibitors and risk of COVID-19 requiring admission to hospital: a case-population study. Lancet. 2020;395(10238):1705-1714. doi:10.1016/S0140-6736(20)31030-8.
Zheng X, Yang H, Li X, et al. Prevalence of Kidney Injury and Associations with Critical Illness and Death in Patients with COVID-19. Clin J Am Soc Nephrol. 2020;15(11):1549-1556. doi:10.2215/CJN.04780420
Pei G, Zhang Z, Peng J, et al. Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia. J Am Soc Nephrol. 2020;31(6):1157-1165. doi:10.1681/ASN.2020030276.
Zhu J, Zhong Z, Ji P, et al. Clinicopathological characteristics of 8697 patients with COVID-19 in China: a meta-analysis [published correction appears in Fam Med Community Health. 2020 May;8(2):]. Fam Med Community Health. 2020;8(2):e000406. doi:10.1136/fmch-2020-000406
Wang J, Jiang M, Chen X, Montaner LJ. Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts. J Leukoc Biol. 2020;108(1):17-41. doi:10.1002/JLB.3COVR0520-272R
Delvaeye M, Conway EM. Coagulation and innate immune responses: can we view them separately?. Blood. 2009;114(12):2367-2374. doi:10.1182/blood-2009-05-199208
Pfister F, Vonbrunn E, Ries T, et al. Complement Activation in Kidneys of Patients With COVID-19. Front Immunol. 2021;11:594849. Published 2021 Jan 29. doi:10.3389/fimmu.2020.594849
Leisman DE, Ronner L, Pinotti R, et al. Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Lancet Respir Med. 2020;8(12):1233-1244. doi:10.1016/S2213-2600(20)30404-5.
Kox M, Waalders NJB, Kooistra EJ, Gerretsen J, Pickkers P. Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions [published online ahead of print, 2020 Sep 3]. JAMA. 2020;324(15):1565-1567. doi:10.1001/jama.2020.17052.
Ferlicot S, Jamme M, Gaillard F, et al. The spectrum of kidney biopsies in hospitalised patients with COVID-19, acute kidney injury, and/or proteinuria [published online ahead of print, 2021 Feb 12]. Nephrol Dial Transplant. 2021;gfab042. doi:10.1093/ndt/gfab042.
S Sharma P, Uppal NN, Wanchoo R, et al. COVID-19-Associated Kidney Injury: A Case Series of Kidney Biopsy Findings. J Am Soc Nephrol. 2020;31(9):1948-1958. doi:10.1681/ASN.2020050699.
Larsen CP, Bourne TD, Wilson JD, Saqqa O, Sharshir MA. Collapsing Glomerulopathy in a Patient With COVID-19. Kidney Int Rep. 2020;5(6):935-939. Published 2020 Apr 9. doi:10.1016/j.ekir.2020.04.002.020.
Akilesh S, Nast CC, Yamashita M, et al. Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria. Am J Kidney Dis. 2021;77(1):82-93.e1. doi:10.1053/j.ajkd.2020.10.001.
Gupta A, Madhavan MV, Sehgal K, et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26(7):1017-1032. doi:10.1038/s41591-020-0968-3.
Jin JM, Bai P, He W, et al. Gender Differences in Patients With COVID-19: Focus on Severity and Mortality. Front Public Health. 2020;8:152. Published 2020 Apr 29. doi:10.3389/fpubh.2020.00152.
Coopersmith CM, Antonelli M, Bauer SR, et al. The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness. Crit Care Med. 2021;49(4):598-622. doi:10.1097/CCM.0000000000004895.
Werion A, Belkhir L, Perrot M, et al. SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule. Kidney Int. 2020;98(5):1296-1307. doi:10.1016/j.kint.2020.07.019.
Yalameha B, Roshan B, Bhaskar LVKS, Mohmoodnia L. Perspectives on the relationship of renal disease and coronavirus disease 2019. J Nephropharmacol. 2020;9(2):e22.
Expert team of consensus of nephrology. Expert consensus on diagnosis and treatment of 2019 novel coronavirus (2019 - nCoV) infection with acute kidney injury. Chin J Nephrol. 2020;12:e005.
Legrand M, Bell S, Forni L, et al. Pathophysiology of COVID-19-associated acute kidney injury. Nat Rev Nephrol. 2021;17(11):751-764. doi:10.1038/s41581-021-00452-0.
Philipponnet C, Aniort J, Chabrot P, Souweine B, Heng AE. Renal artery thrombosis induced by COVID-19. Clin Kidney J. 2020;13(4):713. Published 2020 Aug 5. doi:10.1093/ckj/sfaa141.
El Shamy O, Munoz-Casablanca N, Coca S, Sharma S, Lookstein R, Uribarri J. Bilateral Renal Artery Thrombosis in a Patient With COVID-19. Kidney Med. 2021;3(1):116-119. doi:10.1016/j.xkme.2020.07.010.
Zhang J, Li J, Su L, et al. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2020;32(4):407-411. doi:10.3760/cma.j.cn121430-20200302-00198.
Fominskiy EV, Scandroglio AM, Monti G, et al. Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy. Blood Purif. 2021;50(1):102-109. doi:10.1159/000508657.
Peng S, Wang HY, Sun X, et al. Early versus late acute kidney injury among patients with COVID-19-a multicenter study from Wuhan, China. Nephrol Dial Transplant. 2020;35(12):2095-2102. doi:10.1093/ndt/gfaa288.
Cai X, Wu G, Zhang J, Yang L. Risk Factors for Acute Kidney Injury in Adult Patients With COVID-19: A Systematic Review and Meta-Analysis. Front Med (Lausanne). 2021;8:719472. Published 2021 Dec 6. doi:10.3389/fmed.2021.719472.
Rubin S, Orieux A, Prevel R, et al. Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019. Clin Kidney J. 2020;13(3):354-361. Published 2020 Jun 6. doi:10.1093/ckj/sfaa099.
Williamson EJ, Walker AJ, Bhaskaran K, et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature. 2020;584(7821):430-436. doi:10.1038/s41586-020-2521-4.
Portolés J, Marques M, López-Sánchez P, et al. Chronic kidney disease and acute kidney injury in the COVID-19 Spanish outbreak. Nephrol Dial Transplant. 2020;35(8):1353-1361. doi:10.1093/ndt/gfaa189.
Russo E, Esposito P, Taramasso L, et al. Kidney disease and all-cause mortality in patients with COVID-19 hospitalized in Genoa, Northern Italy. J Nephrol. 2021;34(1):173-183. doi:10.1007/s40620-020-00875-1.
Mohamed MMB, Lukitsch I, Torres-Ortiz AE, et. al. Acute kidney injury associated with coronavirus disease 2019 in urban New Orleans. Kidney360. 2020;1(7):614-622.
Cohen JB, Hanff TC, William P, et al. Continuation versus discontinuation of renin-angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial. Lancet Respir Med. 2021;9(3):275-284. doi:10.1016/S2213-2600(20)30558-0.
Cui X, Yu X, Wu X, et al. Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study. Kidney Blood Press Res. 2020;45(4):612-622. doi:10.1159/000509517.
Arikan H, Ozturk S, Tokgoz B, et al. Characteristics and outcomes of acute kidney injury in hospitalized COVID-19 patients: A multicenter study by the Turkish society of nephrology. PLoS One. 2021;16(8):e0256023. Published 2021 Aug 10. doi:10.1371/journal.pone.0256023.
Orieux A, Rubin S, Prevel R, Garric A, Gruson D, Boyer A. Severe COVID-19-induced AKI: a 3-month follow-up. Clin Kidney J. 2021;14(4):1289-1290. Published 2021 Feb 2. doi:10.1093/ckj/sfab028.
Nugent J, Aklilu A, Yamamoto Y, et al. Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19 [published correction appears in JAMA Netw Open. 2021 Apr 1;4(4):e2111225]. JAMA Netw Open. 2021;4(3):e211095. Published 2021 Mar 1. doi:10.1001/jamanetworkopen.2021.1095.
COVID-ICU Group on behalf of the REVA Network and the COVID-ICU Investigators. Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study. Intensive Care Med. 2021;47(1):60-73. doi:10.1007/s00134-020-06294-x.
Cantaluppi V, Guglielmetti G, Dellepiane S, Marengo M, Mehta RL, Ronco C. A call to action to evaluate renal functional reserve in patients with COVID-19. Am J Physiol Renal Physiol. 2020;319(5):F792-F795. doi:10.1152/ajprenal.00245.2020.
Saggi SJ, Nath S, Culas R, et al. Early Experience With Methylprednisolone on SARS-CoV-2 Infection in the African American Population, a Retrospective Analysis. Clin Med Insights Circ Respir Pulm Med. 2020;14:1179548420980699. Published 2020 Dec 14. doi:10.1177/1179548420980699.
Saggi SJ, Nath S, Culas R, et al. Early Experience With Methylprednisolone on SARS-CoV-2 Infection in the African American Population, a Retrospective Analysis. Clin Med Insights Circ Respir Pulm Med. 2020;14:1179548420980699. Published 2020 Dec 14. doi:10.1177/1179548420980699.
Ronco C, Reis T, Husain-Syed F. Management of acute kidney injury in patients with COVID-19. Lancet Respir Med. 2020;8(7):738-742. doi:10.1016/S2213-2600(20)30229-0.
Sohaney R, Shaikhouni S, Ludwig JT, et al. Continuous Renal Replacement Therapy among Patients with COVID-19 and Acute Kidney Injury [published online ahead of print, 2021 Nov 2]. Blood Purif. 2021;1-8. doi:10.1159/000518713.
Guirguis JK, Yenebere P, Sher SJ, Kelly KJ. Lower continuous venovenous hemodialysis replacement rate and its effect on patient outcome in the COVID crisis time. JASN. 2020;31:258.
American Society of Nephrology. Recommendations on the care of hospitalized patients with COVID-19 and kidney failure requiring renal replacement therapy. 2020.
Pannu N, James M, Hemmelgarn B, Klarenbach S; Alberta Kidney Disease Network. Association between AKI, recovery of renal function, and long-term outcomes after hospital discharge. Clin J Am Soc Nephrol. 2013;8(2):194-202. doi:10.2215/CJN.06480612.
Leclerc S, Royal V, Lamarche C, Laurin LP. Minimal Change Disease With Severe Acute Kidney Injury Following the Oxford-AstraZeneca COVID-19 Vaccine: A Case Report. Am J Kidney Dis. 2021;78(4):607-610. doi:10.1053/j.ajkd.2021.06.008
Lebedev L., Sapojnikov M., Wechsler A. Minimal change disease following the Pfizer-BioNTech COVID-19 vaccine. Am J Kidney Dis. 2021;78(1):142–145. doi: 10.1053/j.ajkd.2021.03.010.
D’Agati VD, Kudose S, Bomback AS, Adamidis A, Tartini A. Minimal change disease and acute kidney injury following the Pfizer-BioNTech COVID-19 vaccine. Kidney Int. 2021;100(2):461-463. doi:10.1016/j.kint.2021.04.035
Maas R.J., Gianotten S., van der Meijden W.A.G. An additional case of minimal change disease following the Pfizer-BioNTech COVID-19 vaccine. Am J Kidney Dis. 2021;78(2):312. doi: 10.1053/j.ajkd.2021.05.003.
Kervella D, Jacquemont L, Chapelet-Debout A, Deltombe C, Ville S. Minimal change disease relapse following SARS-CoV-2 mRNA vaccine. Kidney Int. 2021;100(2):457-458. doi:10.1016/j.kint.2021.04.033
Morlidge C, El-Kateb S, Jeevaratnam P, Thompson B. Relapse of minimal change disease following the AstraZeneca COVID-19 vaccine. Kidney Int. 2021;100(2):459. doi:10.1016/j.kint.2021.06.005
Klomjit N, Alexander MP, Fervenza FC, et al. COVID-19 Vaccination and Glomerulonephritis. Kidney Int Rep. 2021;6(12):2969-2978. doi:10.1016/j.ekir.2021.09.008
Hanna C, Herrera Hernandez LP, Bu L, et al. IgA nephropathy presenting as macroscopic hematuria in 2 pediatric patients after receiving the Pfizer COVID-19 vaccine. Kidney Int. 2021;100(3):705-706. doi:10.1016/j.kint.2021.06.032
Hanna C, Herrera Hernandez LP, Bu L, et al. IgA nephropathy presenting as macroscopic hematuria in 2 pediatric patients after receiving the Pfizer COVID-19 vaccine. Kidney Int. 2021;100(3):705-706. doi:10.1016/j.kint.2021.06.032
Sekar A, Campbell R, Tabbara J, Rastogi P. ANCA glomerulonephritis after the Moderna COVID-19 vaccination. Kidney Int. 2021;100(2):473-474. doi:10.1016/j.kint.2021.05.017
Shakoor MT, Birkenbach MP, Lynch M. ANCA-Associated Vasculitis Following Pfizer-BioNTech COVID-19 Vaccine. Am J Kidney Dis. 2021;78(4):611-613. doi:10.1053/j.ajkd.2021.06.016
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